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Tumor Immunology and Tumor Evolution: Intertwined Histories

Galon and Daniela Bruni 2020 ; https://doi.org/10.1016/j.immuni.2019.12.08, attached Cancer is a complex disease whose outcome depends largely on the cross-talk between the tumor and its microenvironment. Here, we review the evolution of the field of tumor immunology and the advances, in lockstep, of our understanding of cancer as a disease. We discuss the involvement of different […]

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Snake Venom Gland Organoids

Post et al., 2020, Cell 180, 233–247, https://www.sciencedirect.com/sdfe/reader/pii/S0092867419313236/pdf, open access The establishment of venom gland organoids from a variety of snake species allows for the production and harvest of different types of toxins of biological interest. Snake venom gland cells can be cultured as adult-stem-cell based organoids Organoids contain proliferating progenitors and various venom-producing cells […]

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Adolescents’ perceptions of family social status correlate with health and life chances: A twin difference longitudinal cohort study

Joshua et al., 2020; PNAS first published January 6, 2020 , https://doi.org/10.1073/pnas.1820845116, open access Young people who think their families are high status tend to have better mental health than teens with a more modest perception of their families.  Teenagers’ health is linked to how they view their families Socioeconomic factors are less important than an adolescent’s […]

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A novel interstitial deletion of chromosome 2q21.1-q23.3: Case report and literature review

Bader Almuzzaini et al., 2020, Mol Genet Genomic Med. 2020;00:e1135. , https://doi.org/10.1002/mgg3.11, open access We describe a preterm male harboring a novel interstitial deletion encompassing the 2q21.2-q23.3 region of 2q, a deletion that has not been described previously. The patient had multiple congenital anomalies including agenesis of the corpus callosum, congenital cardiac defects, bilateral hydronephrosis, […]

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Therapeutic E_cacy of Nyctanthes arbor-tristis Flowers to Inhibit Proliferation of Acute and Chronic Primary Human Leukemia Cells, with Adipocyte Di_erentiation and in Silico Analysis of Interactions between Survivin Protein and Selected Secondary Metabolites

Heendeniya et al., 2020 Biomolecules 2020, 10, 165; doi:10.3390/biom10020165, open access Although the antidiabetic e_cacy of Nyctanthes arbor-tristis flowers has been reported, antiproliferative and anti-obesity activities are yet to be explored. We examined the anti-obesity and antiproliferative potentials of different fractions (hexane, chloroform, ethyl acetate, methanol) of N. abor-tristis flower extract for the first time […]

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Functional Binding of E-selectin to its Ligands is Enhanced by Structural Features Beyond its Lectin Domain

Fajr A. Aleisa et al., 2020  http://www.jbc.org/cgi/doi/10.1074/jbc.RA119.010910, attached Using various Eselectin constructs produced in a newly developed silkworm-based expression system and several assays performed under both static and physiological flow conditions, including flow cytometry, glycan array analysis, surface plasmon resonance, and cell-rolling assays, we show here that a reduction in the number of SCR domains […]

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Proteomic and Molecular Assessment of the Common Saudi Variant in ACADVL Gene Through Mesenchymal Stem Cells

Ahmad Alfares et al. 2020, Frontiers in Cell and Developmental Biology | www.frontiersin.org 2 January 2020 | Volume 7 | Article 365, attached Very-long-chain acyl-coenzyme A dehydrogenase (VLCAD) is a coenzyme encoded by ACADVL that converts very-long-chain fatty acids into energy. This process is disrupted by c.65C > A; p.Ser22_ mutation. Saudi Arabia have a […]

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HMOX1 is partly responsible for phenotypic and functional abnormalities in mesenchymal stem cells/stromal cells from placenta of preeclampsia (PE) patients

Basmaeil et al. Stem Cell Research & Therapy (2020) 11:30, open access We have isolated and characterized MSCs from decidua basalis of preeclampsia placenta (PE-DBMSCs) and showed their decreased functionality in terms of proliferation, migration, adhesion and clone formation potential as compared to MSCs isolated from decidua region of normal placentae (DBMSCs). Our results suggest […]

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