Snake Venom Gland Organoids

Snake Venom Gland Organoids

Post et al., 2020, Cell 180, 233–247, https://www.sciencedirect.com/sdfe/reader/pii/S0092867419313236/pdf, open access

The establishment of venom gland organoids from a variety of snake species allows for the production and harvest of different types of toxins of biological interest.

  • Snake venom gland cells can be cultured as adult-stem-cell based organoids
  • Organoids contain proliferating progenitors and various venom-producing cells
  • Regional and cellular heterogeneity of venom components is maintained in culture
  • Venom gland organoids secrete functionally active toxins
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