Snake Venom Gland Organoids
Post et al., 2020, Cell 180, 233–247, https://www.sciencedirect.com/sdfe/reader/pii/S0092867419313236/pdf, open access
The establishment of venom gland organoids from a variety of snake species allows for the production and harvest of different types of toxins of biological interest.
- Snake venom gland cells can be cultured as adult-stem-cell based organoids
- Organoids contain proliferating progenitors and various venom-producing cells
- Regional and cellular heterogeneity of venom components is maintained in culture
- Venom gland organoids secrete functionally active toxins