Snake Venom Gland Organoids

• Post by: Mohamed Boudjelal
• 23 February 2020
• No Comment

Post et al., 2020, Cell 180, 233–247, https://www.sciencedirect.com/sdfe/reader/pii/S0092867419313236/pdf, open access

The establishment of venom gland organoids from a variety of snake species allows for the production and harvest of different types of toxins of biological interest.

• Snake venom gland cells can be cultured as adult-stem-cell based organoids
• Organoids contain proliferating progenitors and various venom-producing cells
• Regional and cellular heterogeneity of venom components is maintained in culture
• Venom gland organoids secrete functionally active toxins